Which antiemetic option is appropriate after Ketamine as described in the material?

• A. Phenergan 12.5 mg
• B. Ondansetron 4 mg
• C. Prochlorperazine 10 mg
• D. Dimenhydrinate 25 mg

Answer: (A)

After ketamine, the goal is reliable antiemesis that also helps calm the patient during recovery. Promethazine (Phenergan) at 12.5 mg provides strong antiemetic action through histamine H1 blockade and adds anticholinergic effects, which help reduce nausea and vomiting and can lessen unease as ketamine wears off. Its sedative properties are advantageous in a field setting, helping to settle the patient after ketamine administration. Other options exist, but they carry trade-offs in this context: some may pose risks of QT prolongation, extrapyramidal symptoms, or less robust antiemetic effect or sedation. For these reasons, Phenergan at 12.5 mg is the best choice described.